Vitamin C lowers histamine levels

Lower the histamine level with natural medicine - vitamin C infusion supported

The working group of Professor Dr. med. Martin Raithel at the University Clinic Erlangen recently investigated whether vitamin C infusions can lower increased histamine levels. Histamine is an endogenous messenger substance, the concentration of which increases in the blood and tissue during allergic reactions, infections and inflammations and which is responsible for many unpleasant symptoms. Since these diseases are often associated with a vitamin C deficiency [1-3], Dr. med. Alexander Hagel and colleagues asked 89 patients with allergies and infections whether a single infusion with the drug Pascorbin® can lower the histamine blood level. To do this, they determined the histamine blood levels before and after the infusion of 7.5 g of vitamin C in 19 patients with allergies and 70 patients with infections.

As expected, the mean histamine levels were significantly higher in patients with allergies than in patients with infections. In allergy sufferers, the histamine levels could be almost halved by the single infusion (Fig. 1).

The initial values ​​in patients with infections were significantly lower, some were even in the normal range, and were reduced by an average of 23.3%.

It is interesting to note that the reduction effect of vitamin C is related to the initial concentration of histamine: the higher the initial histamine values, the more pronounced the reduction effect of vitamin C. no significant changes.

In this study, only the histamine level, but not the symptoms of high histamine levels, was determined or queried. Nevertheless, doctors suspect that the therapeutic benefit of vitamin C infusions, which is often observed in diseases with excessively high histamine levels, is closely related to the histamine reduction.

Fig. 1: Histamine level in the blood before (green) and after (orange) a single infusion with Pascorbin® 7.5g in patients with allergies (19 patients) and infections (70 patients).
Publication Hagel, A. F., Layritz C.M., et al. (2013). "Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases." Naunyn Schmiedeberg's Arch Pharmacol.

1. Aderele, W.I., et al., Plasma vitamin C (ascorbic acid) levels in asthmatic children. Afr J Med Med Sci, 1985. 14 (3-4): p. 115-20.
2. Unal, M., et al., Serum levels of antioxidant vitamins, copper, zinc and magnesium in children with chronic rhinosinusitis. J Trace Elem Med Biol, 2004. 18 (2): p. 189-92.
3. Chen, J.Y., et al., Plasma vitamin C is lower in postherpetic neuralgia patients and administration of vitamin C reduces spontaneous pain but not brush-evoked pain. Clin J Pain, 2009. 25 (7): p. 562-9.

Pascorbin®
Active ingredient: ascorbic acid 150 mg per ml solution for injection. Areas of application: for the therapy of clinical vitamin C deficiencies that cannot be remedied nutritionally or orally substituted. Methemoglobinemia in childhood. Contains sodium hydrogen carbonate. Status: January 2014.
For information on risks and side effects, read the package insert and ask your doctor or pharmacist. Pascoe pharmaceutical preparations GmbH, D-35383 Giessen, [email protected], www.pascoe.de

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