What are chemical reaction hazards

Hazardous chemical reactions

Categories: Organic Chemistry >> Synthesis >> Safety, Toxicology

Lutz Roth, Ursula Weller

Edition 12/2003
ISBN: 3-609-48040-8

Loose-leaf work
Lutz Roth, Ursula Weller

ISBN: 3-609-73090-0


Practical data and case collection on chemical reactions:

Reaction partners and reaction hazards such as explosions, inflammations, development of toxic gases and vapors and heat generation.

This work provides important information on the assessment of substances - when must dangerous chemical reactions be expected? In the form of tables, typical accident reports and information on the properties of individual substances, an overview of the dangerous chemical reactions known today is given.

Editor's opinion

The chemist is used to working with toxic substances. If he takes all precautionary measures, he is not exposed to any major health risk. In addition to the danger posed by the pure starting materials and solvents, however, it must be noted that when substances are mixed, reactions can take place that can no longer be controlled. It is really not about saponifying an ester with ethanolic sodium hydroxide solution, but generally about the countless reactions and groups of substances with which one has not yet been able to gain experience.

The present directory "Dangerous Chemical Reactions", which contains a large number of substance groups and solvents and lists known dangerous reactions (described in the literature), is of great help. With over 1750 substances and groups of substances, for which all dangerous reaction partners are compiled, you can assume that you will find valuable information (in tabular form) on many starting materials and combinations of reagents.

But the collection has some interesting, instructive additional information to offer. And I would recommend everyone to be sure to read the discussion about everyday solvents. Often times one unconsciously uses the usual solvent for recrystallization or extraction, which can have devastating consequences.

For example, under acetone you will find the following entry: "Mixtures of acetone and chloroform can explode if traces of alkali are present. These solvents, which are widely used in laboratories, must not be brought together in waste containers." Of course, this information can also be read under chloroform: "If traces of alkali hydroxide are present, chloroform can react violently exothermically with acetone. 1,1,1-trichloro-2-hydroxy-2-methylpropane is formed, risk of explosion!" The slight change does not interfere here, because the essentials are correctly contained in both places.

The CD-ROM gives you access to all combinations within a very short time. Especially in the example of acetone and chloroform, you have to reckon with a few minutes of searching within the leaf collection. The collection is wonderfully suited to rummaging around a little during breaks in the laboratory work - if there is no PC nearby.

The CD-ROM also allows the information on individual substances to be printed out quickly, so that the most important data is also available at the workplace. The downside is the limited export function, which creates html files, but which cannot be sent without further ado. Because all symbols are located outside of the generated document. Apart from these restrictions, both CD-ROM and the loose-leaf collection can be highly recommended!

Anyone who deals professionally with the safety aspects of chemical reactions will definitely have to purchase a copy. But the collection belongs in the libraries of every company and university in which chemical reactions are carried out. A copy should be ready to hand near the laboratory - or installed on a computer!

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