What are the medical uses of cimetidine


Synonyms: cimetidine hydrochloride, etc.
Trade name: H2 Blocker-ratiopharm
English: cimetidine

1 definition

Cimetidine is an active pharmaceutical ingredient from the group of H2-receptor antagonists, which is used in the prophylaxis and therapy of acid-related stomach complaints to inhibit gastric acid production.

2 indications

Cimetidine is indicated in the treatment of the following conditions:

3 General

The drug is applied in the form of a solution for injection. Cimetidine has a bioavailability of 60 to 70%. In the blood, 15 to 20% of the active substance is bound to plasma proteins. The metabolism takes place hepatically. The plasma half-life averages two hours. The drug is eliminated renally.

4 Mechanism of Action

Cimetedin inhibits the activity of the parietal cells of the stomach and thus serves to reduce the release of gastric acid.

5 Adverse drug reactions

  • Hypersensitivity
  • Headache, chest pain, joint pain, muscle pain
  • Dizziness, insomnia, depression, hallucinations, restlessness
  • Erectile dysfunction, gynecomastia
  • allergic skin reactions: itching, rash
  • Gastrointestinal disorders: diarrhea, nausea, vomiting, abdominal pain
  • Cardiac arrhythmias

6 interactions

Cimetidine inhibits some isoenzymes of the cytochrome P450 system. This mechanism is the basis of numerous drug interactions, such as with phenytoin or theophylline.

7 contraindications